Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

ACE InhibitorsQuinapril2.5-10mg PO Q24HAdminister Anytime During HD; Post HD if Hypotensive

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
43830 (active drug); 96% (quinaprilat)1-2 (active drug); 3 (quinaprilat)6-15971.515.412 (low flux)


  • Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00881
  • Tsuruoka S, Kitoh Y, Kawaguchi A, et al. Clearance of imidapril, an Angiotensin-converting enzyme inhibitor, during hemodialysis in hypertensive renal failure patients: comparison with quinapril and enalapril. Journal of clinical pharmacology. 2007; 47(2):259-63.
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