Doxazosin
| Drug Category | Drug | IHD Dosing | Administration Timing Around HD Session |
|---|---|---|---|
| Alpha Adrenergic Blockers | Doxazosin | 1-8mg PO QHS | Administer Anytime During HD; Post HD if Hypotensive |
Molecular Weight (Da) | Excreted Unchanged (%) | Normal Half-Life (Hours) | ESRD Half-Life (Hours) | Plasma Protein Binding (%) | Volume of Distribution (L/kg) | Dialytic Plasma Clearance (ml/min) | % Dialyzed |
|---|---|---|---|---|---|---|---|
| 451 | <5 | 16-22 | Unchanged | 98 | 1.0-1.7 | N/A | Minimal (low flux) |
References:
- Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
- Carlson R, Bailey R, Begg E, Cowlishaw M, Sharman J. Pharmacokinetics and effect on blood pressure of doxazosin in normal subjects and patients with renal failure. Clinical pharmacology and therapeutics. 1986;40(5):561-6.
- DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00590
- Inrig J. Antihypertensive agents in hemodialysis patients: a current perspective. Seminars in dialysis. 2010;23(3):290-7.