Tramadol
| Drug Category | Drug | IHD Dosing | Administration Timing Around HD Session |
|---|---|---|---|
| Analgesics (Misc.) | Tramadol | 50-100 mg PO Q12H PRN (Do not use sustained release tablets) | Administer Post-HD; if administer on HD, may need to supplement post HD |
Molecular Weight (Da) | Excreted Unchanged (%) | Normal Half-Life (Hours) | ESRD Half-Life (Hours) | Plasma Protein Binding (%) | Volume of Distribution (L/kg) | Dialytic Plasma Clearance (ml/min) | % Dialyzed |
|---|---|---|---|---|---|---|---|
| 263 | 30 | 5.5-7 | N/A | 20 | 2.6-2.9 | 163.5 | 54.5 (high flux) |
References:
- DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00193
- Izzedine H, Launay-Vacher V, Abbara C, et al. Pharmacokinetics of tramadol in a hemodialysis patient. Nephron. 2002;92(3):755-6.