Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

Analgesics (Misc.)Tramadol50-100 mg PO Q12H PRN (Do not use sustained release tablets)Administer Post-HD; if administer on HD, may need to supplement post HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
263305.5-7N/A202.6-2.9163.554.5 (high flux)


  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL:
  • Izzedine H, Launay-Vacher V, Abbara C, et al. Pharmacokinetics of tramadol in a hemodialysis patient. Nephron. 2002;92(3):755-6.