Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

Angiotensin II Receptor BlockersLosartan50-100mg PO Q24HAdminister Anytime During HD; Post HD if Hypotensive

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
4234-102.5-5.44-6980.45N/A0 (high flux)


  • Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00678
  • Inrig J. Antihypertensive agents in hemodialysis patients: a current perspective. Seminars in dialysis. 2010;23(3):290-7.
  • Sica D, Halstenson C, Gehr T, Keane W. Pharmacokinetics and blood pressure response of losartan in end-stage renal disease. Clinical pharmacokinetics. 2000;38(6):519-26.
  • Toto R, Shultz P, Raij L, et al. Efficacy and Tolerability of Losartan in Hypertensive Patients With Renal Impairment. Hypertension. 1998;31:684-691.