Amoxicillin
| Drug Category | Drug | IHD Dosing |
Administration Timing Around HD Session |
|---|---|---|---|
| Antibiotics | Amoxicillin | 500mg PO Q12-24H | Administer Post-HD |
|
Molecular Weight (Da) | Excreted Unchanged (%) | Normal Half-Life (Hours) | ESRD Half-Life (Hours) | Plasma Protein Binding (%) | Volume of Distribution (L/kg) | Dialytic Plasma Clearance (ml/min) | % Dialyzed |
|---|---|---|---|---|---|---|---|
| 365 | 50-70 | 0.9-2.3 | 5-20 | 15-25 | 0.26 | 58.9-83.6 | 30-47.2 (low flux) |
References:
- Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
- Davies B, Boon R, Horton R, Reubi F, Descoeudres C. Pharmacokinetics of amoxycillin and clavulanic acid in haemodialysis patients following intravenous administration of Augmentin. British journal of clinical pharmacology 1988; 26(4), 385-90.
- DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB01060
- Horber F, Frey F, Descoeudres C, Murray A, Reubi F. Differential Effect of Impaired Renal Function on the Kinetics of Clavulanic Acid and Amoxicillin. Antimicrobial agents and chemotherapy 1986; 29(4), 614-9.
- Humbert G, Spyker D, Leroy A, Humbert G, Fillastre I. Pharmacokinetics of Amoxicillin : Dosage Nomogram for Patients with Impaired Renal Function. Antimicrobial agents and chemotherapy 1979; 15(1), 28-33.
- Lawson D, Henderson A, McGeachy R. Amoxycillin: pharmacokinetic studies in normal subjects, patients with pernicious anaemia and those with renal failure. Postgraduate medical journal 1974; 50(586), 500-3.
- Matzke, G. Status of Hemodialysis of Drugs in 2002. Journal of Pharmacy Practice 2002; 15(5), 405-418.
- Slaughter R, Kohli R, Brass C. Effects of Hemodialysis on the Pharmacokinetics of Amoxicillin/Clavulanic Acid Combination. Therapeutic Drug Monitoring 1984; 6, 424-7.