Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

AntibioticsAmoxicillin500mg PO Q24HAdminister Post-HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
36550-700.9-2.35-2015-250.2658.9-83.630-47.2 (low flux)


  • Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
  • Davies B, Boon R, Horton R, Reubi F, Descoeudres C. Pharmacokinetics of amoxycillin and clavulanic acid in haemodialysis patients following intravenous administration of Augmentin. British journal of clinical pharmacology 1988; 26(4), 385-90.
  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL:
  • Horber F, Frey F, Descoeudres C, Murray A, Reubi F. Differential Effect of Impaired Renal Function on the Kinetics of Clavulanic Acid and Amoxicillin. Antimicrobial agents and chemotherapy 1986; 29(4), 614-9.
  • Humbert G, Spyker D, Leroy A, Humbert G, Fillastre I. Pharmacokinetics of Amoxicillin : Dosage Nomogram for Patients with Impaired Renal Function. Antimicrobial agents and chemotherapy 1979; 15(1), 28-33.
  • Lawson D, Henderson A, McGeachy R. Amoxycillin: pharmacokinetic studies in normal subjects, patients with pernicious anaemia and those with renal failure. Postgraduate medical journal 1974; 50(586), 500-3.
  • Matzke, G. Status of Hemodialysis of Drugs in 2002. Journal of Pharmacy Practice 2002; 15(5), 405-418.
  • Slaughter R, Kohli R, Brass C. Effects of Hemodialysis on the Pharmacokinetics of Amoxicillin/Clavulanic Acid Combination. Therapeutic Drug Monitoring 1984; 6, 424-7.