Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

AntibioticsCefixime200mg Q24HAdminister Post-HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
45318-503.112500.6-1.10.50 (low flux)


  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00671
  • Faulkner R, Yacobi A, Barone J, Kaplan S, Silber M. Pharmacokinetic Profile of Cefixime in Man. Pediatric Infectious Diseases Journal 1987; 6, 963-70.
  • Guay D, Meatherall R, Harding G, Brown G. Pharmacokinetics of Cefixime (CL 284 , 635 ; FK 027 ) in Healthy Subjects and Patients with Renal Insufficiency. Antimicrobial agents and chemotherapy 1986; 30(3), 485-90.