Cephalexin
| Drug Category | Drug | IHD Dosing | Administration Timing Around HD Session |
|---|---|---|---|
| Antibiotics | Cephalexin | 250-500mg PO Q12H | Administer Post-HD |
Molecular Weight (Da) | Excreted Unchanged (%) | Normal Half-Life (Hours) | ESRD Half-Life (Hours) | Plasma Protein Binding (%) | Volume of Distribution (L/kg) | Dialytic Plasma Clearance (ml/min) | % Dialyzed |
|---|---|---|---|---|---|---|---|
| 347 | 98 | 0.7 | 16 | 20 | 0.35 | N/A | 51 (low flux) |
References:
- Andriole V. Pharmacokinetics of Cephalosporin in Patients with Normal or Reduced Renal Function. Journal of Infectious Diseases 1987; 137(Supplement), S88-97.
- Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
- DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00567
- Kabins S, Kelner B, Walton E, Goldstein E. Cephalexin Therapy as Related to Renal Function. The American journal of the medical sciences 1970; 259, 133-42.