Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

Antibiotics Ciprofloxacin 250-500mg PO or 200-400mg IV Q24H Administer Post-HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
331 50-70 3-6 6-9 20-40 2.5 40-57.2 23-31 (low flux)


  • Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
  • Boelaert J, Valcke Y, Schurgers M et al. The pharmacokinetics of ciprofloxacin in patients with impaired renal function. The Journal of antimicrobial chemotherapy 1985; 16(1), 87-93.
  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL:
  • Fillastre J, Leroy A, Moulin B, Dhib M, Borsa-Lebas F, Humbert G. Pharmacokinetics of quinolones in renal insufficiency. The Journal of antimicrobial chemotherapy 1990; 26(Suppl B), 51-60.
  • Forrest A, Weir M, Plaisance K, Drusano G, Leslie J, Standiford H. Relationships between Renal Function and Disposition of Oral Ciprofloxacin. Microbiology 1988; 32(10).
  • Heintz B, Matzke G, Dager W. Antimicrobial dosing concepts and recommendations for critically ill adult patients receiving continuous renal replacement therapy or intermittent hemodialysis. Pharmacotherapy 2009; 29(5), 562-77.
  • Hoffken G, Lode H, Prinzing C, Borner K, Koeppe P. Pharmacokinetics of Ciprofloxacin after Oral and Parenteral Administration. Microbiology 1985; 27(3).
  • Shah A, Lettieri J, Blum R, Millikin S, Sica D, Heller A. Pharmacokinetics of intravenous ciprofloxacin in normal and renally impaired subjects. The Journal of antimicrobial chemotherapy 1996; 38(1), 103-16.
  • Singlas E, Taburet A, Landru L, Albin H, Ryckelinck J. Pharmacokinetics of ciprofloxacin tablets in renal failure; influence of haemodialysis. European journal of clinical pharmacology 1987; 31(5), 589-93.
  • Wolfson J, Hooper D. Pharmacokinetics of quinolones: newer aspects. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1991; 10(4), 267-74.