Ciprofloxacin
| Drug Category | Drug | IHD Dosing |
Administration Timing Around HD Session |
|---|---|---|---|
| Antibiotics | Ciprofloxacin | 250-500mg PO or 200-400mg IV Q24H | Administer Post-HD |
|
Molecular Weight (Da) | Excreted Unchanged (%) | Normal Half-Life (Hours) | ESRD Half-Life (Hours) | Plasma Protein Binding (%) | Volume of Distribution (L/kg) | Dialytic Plasma Clearance (ml/min) | % Dialyzed |
|---|---|---|---|---|---|---|---|
| 331 | 50-70 | 3-6 | 6-9 | 20-40 | 2.5 | 40-57.2 | 23-31 (low flux) |
References:
- Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
- Boelaert J, Valcke Y, Schurgers M et al. The pharmacokinetics of ciprofloxacin in patients with impaired renal function. The Journal of antimicrobial chemotherapy 1985; 16(1), 87-93.
- DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00537
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