Ertapenem

Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

Antibiotics Ertapenem 500mg IV Q24H Administer Post-HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
475 38 4 6 85-95 8.2 19 30 (N/A)

References:

  • Burkhardt O, Hafer C, Langhoff A et al. Pharmacokinetics of ertapenem in critically ill patients with acute renal failure undergoing extended daily dialysis. Nephrology, dialysis, transplantation (official publication of the European Dialysis and Transplant Association - European Renal Association) 2009; 24(1), 267-71.
  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00303
  • Embil J, Gin A, Hoban D, Johanson C, Noreddin A, Vercaigne L. Ertapenem: review of a new carbepenm. Expert Review of Anti-Infective Therapy 2005; 3(1), 23.
  • Mistry G, Majumdar A, Swan S et al. Pharmacokinetics of ertapenem in patients with varying degrees of renal insufficiency and in patients on hemodialysis. Journal of clinical pharmacology 2006; 46(10), 1128-38.