Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

AntibioticsTigecyclineLD 100mg IV, then 50mg IV Q12HAdminister Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
5862242N/A71-897-9N/A0 (N/A)


  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00560
  • Heintz B, Matzke G, Dager W. Antimicrobial dosing concepts and recommendations for critically ill adult patients receiving continuous renal replacement therapy or intermittent hemodialysis. Pharmacotherapy 2009; 29(5), 562-77.
  • Meagher A, Ambrose P, Grasela T, Ellis-Grosse E. The pharmacokinetic and pharmacodynamic profile of tigecycline. Clinical infectious diseases (an official publication of the Infectious Diseases Society of America) (2005); 41(Suppl 5), S333-40.