Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

Antiemetics Ondansetron 8mg PO/IV Q8H Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
293.36 <5 2.5-5.5 unchanged 70-76% 2 N/A N/A


    • Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
    • DrugBank [Online]. 2013 Feb 06 [cited 2013 Feb 06]; Available from: URL: http://www.drugbank.ca/
    • Ondansetron. In: Lexi-Drugs Online. Hudson (OH): Lexi-Comp, Inc,; [updated 02/06/13; accessed 02/06/13].