Amphotericin B

Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

AntifungalsAmphotericin BNormal dose based on indicationAdminister Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
9245-1024 (hrs)- 15 daysUnchanged90413.5-200 (high flux)


  • Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
  • Banks R, Williams A, Glover S, Burton P, Warnock D, Mackenzie C. Disseminated cryptococcosis in a patient receiving chronic haemodialysis. Postgraduate medical journal 1985; 61(718), 745-7.
  • Block E, Bennett J, Livoti L, Klein W. Flucytosine and Amphotericin B: Hemodialysis Effects on the Plasma Concentration and Clearance. Annals of internal medicine 1974; 80, 613-7.
  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL:
  • Feldman H, Hamilton J, Gutman R. Amphotericin B Therapy in an Anephric Patient. Antimicrobial agents and chemotherapy 1973; 4(3), 302-305.
  • Gandhi B, Bahadur M, Dodeja H, Aggrwal V, Thamba A, Mali M. Systemic fungal infections in renal diseases. Journal of postgraduate medicine 2005; 51(Suppl 1), S30-6.
  • Gussak H, Rahman S, Bastani B. Administration and clearance of amphotericin B during high-efficiency or high-efficiency/high-flux dialysis. American Journal of Kidney Diseases 2001; 37(6), E45.
  • Heinemann V, Bosse D, Jehn U et al. Pharmacokinetics of liposomal amphotericin B (Ambisome) in critically ill patients. Pharmacokinetics of Liposomal Amphotericin B (AmBisome) in Critically Ill Patients. Microbiology 1997; 41(6).
  • Heintz B, Matzke G, Dager W. Antimicrobial dosing concepts and recommendations for critically ill adult patients receiving continuous renal replacement therapy or intermittent hemodialysis. Pharmacotherapy 2009; 29(5), 562-77.
  • Polak A. Pharmacokinetics of amphotericin B and flucytosine. Postgraduate medical journal 1979; 55(September), 667-670.
  • Wood J, Mahnensmith M, Mahnensmith R, Perazella M. Intradialytic administration of amphotericin B: clinical observations on efficacy and safety. The American journal of the medical sciences 2004; 327(1), 5-8.