Pentamidine isethionate
Drug Category | Drug | IHD Dosing | Administration Timing Around HD Session |
---|---|---|---|
Antifungals | Pentamidine isethionate | 4mg/kg IV Q24-36H | Administer Anytime During HD |
Molecular Weight (Da) | Excreted Unchanged (%) | Normal Half-Life (Hours) | ESRD Half-Life (Hours) | Plasma Protein Binding (%) | Volume of Distribution (L/kg) | Dialytic Plasma Clearance (ml/min) | % Dialyzed |
---|---|---|---|---|---|---|---|
340 | <5 | 2.8-12 | 73-118 | 69 | 3-4 | 6316 | 0 (N/A) |
References:
- Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
- Conte J, Upton R, Lin E. Pentamidine pharmacokinetics in patients with AIDS with impaired renal function. The Journal of infectious diseases 1987; 156(6), 885-90.
- Conte J. Intravenous Pentamidine Pharmacokinetics in Patients with Normal Renal Function or Receiving Hemodialysis. Journal of Infectious Diseases 1991; 163(1), 169-175.
- DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00738