Pentamidine isethionate

Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

AntifungalsPentamidine isethionate4mg/kg IV Q24-36HAdminister Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
340<52.8-1273-118693-463160 (N/A)


  • Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
  • Conte J, Upton R, Lin E. Pentamidine pharmacokinetics in patients with AIDS with impaired renal function. The Journal of infectious diseases 1987; 156(6), 885-90.
  • Conte J. Intravenous Pentamidine Pharmacokinetics in Patients with Normal Renal Function or Receiving Hemodialysis. Journal of Infectious Diseases 1991; 163(1), 169-175.
  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: