Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

AntifungalsPosaconazoleNormal dose based on indicationAdminister Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
701<0.235N/A>986.6-25.3 (based on 70 kg)14150 (N/A)


  • Cota J, Burgess D. Antifungal Dose Adjustment in Renal and Hepatic Dysfunction : Pharmacokinetic and Pharmacodynamic Considerations. Curr Fungal Infect Rep 2010; 4, 120-128.
  • Courtney R, Sansone A, Smith W et al. Posaconazole Pharmacokinetics, Safety, and Tolerability in Subjects With Varying Degrees of Chronic Renal Disease. Journal of Clinical Pharmacology 2005; 45, 185-92.
  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB01263