Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

Antihistamines Diphenhydramine 25-50mg Q6H PRN Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
255.35 2 5.3-11.7 N/A 80-99 3.3-6.8 N/A N/A


  • Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
  • Diphenhydramine. In: Lexi-Drugs Online. Hudson (OH): Lexi-Comp, Inc,; [updated 02/06/13; accessed 02/06/13].
  • DrugBank [Online]. 2013 Feb 06 [cited 2013 Feb 06]; Available from: URL: http://www.drugbank.ca