Valacyclovir

Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

AntiviralsValacyclovir500mg PO Q24HAdminister Post-HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
32462-9132014-18Widely distributedN/A33-45 (N/A)

References:

  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00577
  • Hoenich N, Levin N. Reply. Nephrology Dialysis Transplantation 2003; 18(12), 2679-2680.
  • Rivkin, A. Valacyclovir-induced seizures in end-stage renal disease. The Annals of pharmacotherapy 2003; 37(12), 1913.
  • Schmidt F, Kastrup A, Na T, Krapf H, Ku W. Letters to the editor. The Ochsner journal 2012; 12(1), 85-6.