Valacyclovir
Drug Category | Drug | IHD Dosing | Administration Timing Around HD Session |
---|---|---|---|
Antivirals | Valacyclovir | 500mg PO Q24H | Administer Post-HD |
Molecular Weight (Da) | Excreted Unchanged (%) | Normal Half-Life (Hours) | ESRD Half-Life (Hours) | Plasma Protein Binding (%) | Volume of Distribution (L/kg) | Dialytic Plasma Clearance (ml/min) | % Dialyzed |
---|---|---|---|---|---|---|---|
324 | 62-91 | 3 | 20 | 14-18 | Widely distributed | N/A | 33-45 (N/A) |
References:
- DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00577
- Hoenich N, Levin N. Reply. Nephrology Dialysis Transplantation 2003; 18(12), 2679-2680.
- Rivkin, A. Valacyclovir-induced seizures in end-stage renal disease. The Annals of pharmacotherapy 2003; 37(12), 1913.
- Schmidt F, Kastrup A, Na T, Krapf H, Ku W. Letters to the editor. The Ochsner journal 2012; 12(1), 85-6.