Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

Beta BlockersSotalol40mg PO Q24HAdminister Post HD session

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
27280-9010-2056<11.2-2.4N/A20 (low flux)


  • Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL:
  • Huynh-Do C, Wahl C, Sulzer M, Buhler H, Keusch G. Torsade de pointes during low-dosage sotalol therapy in haemodialysis patients. Nephrology Dialysis Transplantation. 1996;11:1153-1154.
  • Tjandramaga T, Verbeeck R, Thomas J, et al. The effect of end-stage renal failure and haemodialysis on the elimination kinetics of sotalol. British journal of clinical pharmacology. 1976;3(2):259-65.