Sotalol
| Drug Category | Drug | IHD Dosing | Administration Timing Around HD Session |
|---|---|---|---|
| Beta Blockers | Sotalol | 40mg PO Q24H | Administer Post HD session |
Molecular Weight (Da) | Excreted Unchanged (%) | Normal Half-Life (Hours) | ESRD Half-Life (Hours) | Plasma Protein Binding (%) | Volume of Distribution (L/kg) | Dialytic Plasma Clearance (ml/min) | % Dialyzed |
|---|---|---|---|---|---|---|---|
| 272 | 80-90 | 10-20 | 56 | <1 | 1.2-2.4 | N/A | 20 (low flux) |
References:
- Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
- DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00489
- Huynh-Do C, Wahl C, Sulzer M, Buhler H, Keusch G. Torsade de pointes during low-dosage sotalol therapy in haemodialysis patients. Nephrology Dialysis Transplantation. 1996;11:1153-1154.
- Tjandramaga T, Verbeeck R, Thomas J, et al. The effect of end-stage renal failure and haemodialysis on the elimination kinetics of sotalol. British journal of clinical pharmacology. 1976;3(2):259-65.