Diltiazem

Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

Calcium Channel BlockersDiltiazem120-360mg PO Q24H (sustained release)Administer Anytime During HD; Post HD if Hypotensive

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
414<53-4.4No change75-812.1-4.5N/AN/A

References:

  • Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
  • Diltiazem. In:Lexi-Drugs Online. Hudson (OH): Lexi-Comp, Inc; [updated 04/23/12; accessed 04/23/12].
  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00343
  • Inrig J. Antihypertensive agents in hemodialysis patients: a current perspective. Seminars in dialysis. 2010;23(3):290-7.