Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

Calcium Channel BlockersNifedipine30-90mg PO Q24H (sustained release)Administer Anytime During HD; Post HD if Hypotensive

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
346<525-792-981.42.82.3 (low flux)


  • Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL:
  • Inrig J. Antihypertensive agents in hemodialysis patients: a current perspective. Seminars in dialysis. 2010;23(3):290-7.
  • Martre H, Sari R, Taburet A, Jacobs C, Singlas E. Haemodialysis does not affect the pharmacokinetics of nifedipine. British Journal of Clinical Pharmacology. 1985;20:155-158.