Verapamil

Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

Calcium Channel BlockersVerapamil180-480mg PO Q24H (sustained release)Administer Anytime During HD; Post HD if Hypotensive

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
455<32.8-7.42.4-483-933-7.127Minimal (low flux)

References:

  • Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00661
  • Inrig J. Antihypertensive agents in hemodialysis patients: a current perspective. Seminars in dialysis. 2010;23(3):290-7.
  • Mooy J, Schols M, v Baak M, et al. Pharmacokinetics of verapamil in patients with renal failure. European journal of clinical pharmacology. 1985;28(4):405-10.