Dabigatran

Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

Cardiovascular Medications (Misc.)DabigatranNot RecommendedNot Recommended

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
4728012-1728350.7-1 (based on 70 kg)N/A68 (N/A)

References:

  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB06695
  • Stangier J, Rathgen K, Sta H. Influence of Renal Impairment on the Pharmacokinetics and Pharmacodynamics of Oral Dabigatran Etexilate. Clinical pharmacokinetics. 2010;49(4):259-268.