Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

Diabetes MedicationsGlyburideNot recommendedAdminister Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
494501.4-2.9 (12-15 with chronic use)5990.16-0.3N/A No (N/A)


  • Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
  • Brier M, Bays H, Sloan R, et al. Pharmacokinetics of oral glyburide in subjects with non-insulin-dependent diabetes mellitus and renal failure. American journal of kidney diseases (the official journal of the National Kidney Foundation) 1997;29(6):907-11.
  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: