Insulin Glargine

Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

Diabetes MedicationsInsulin GlargineAdminister 25-50% of normal dose and titrateAdminister Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed


  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL:
  • Iglesias P, Díez J. Insulin therapy in renal disease. Diabetes, obesity & metabolism. 2008;10(10):811-23.