Azathioprine
Drug Category | Drug | IHD Dosing | Administration Timing Around HD Session |
---|---|---|---|
Immunosuppressants | Azathioprine | Varies based on indication; 50% of normal dose | Administer Post-HD |
Molecular Weight (Da) | Excreted Unchanged (%) | Normal Half-Life (Hours) | ESRD Half-Life (Hours) | Plasma Protein Binding (%) | Volume of Distribution (L/kg) | Dialytic Plasma Clearance (ml/min) | % Dialyzed |
---|---|---|---|---|---|---|---|
277 | <2 | 0.2 (parent drug); 0.7-3 (mercaptopurine) | Slightly prolonged | 30 | 0.55-0.8 | N/A | 45 (N/A) |
References:
- DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00993
- a. Swarup A, Sachdeva N, Schumacher H. Dosing of Antirheumatic Drugs in Renal Disease and Dialysis. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2004; 10(4), 190-204.