Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

ImmunosuppressantsAzathioprineVaries based on indication; 50% of normal dose Administer Post-HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
277<20.2 (parent drug); 0.7-3 (mercaptopurine)Slightly prolonged300.55-0.8N/A45 (N/A)


  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL:
  • a. Swarup A, Sachdeva N, Schumacher H. Dosing of Antirheumatic Drugs in Renal Disease and Dialysis. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2004; 10(4), 190-204.