Cyclosporine
| Drug Category | Drug | IHD Dosing | Administration Timing Around HD Session |
|---|---|---|---|
| Immunosuppressants | Cyclosporine | Varies based on indication and serum concentration | Administer Anytime During HD |
Molecular Weight (Da) | Excreted Unchanged (%) | Normal Half-Life (Hours) | ESRD Half-Life (Hours) | Plasma Protein Binding (%) | Volume of Distribution (L/kg) | Dialytic Plasma Clearance (ml/min) | % Dialyzed |
|---|---|---|---|---|---|---|---|
| 1203 | <1 | 3-16 | Unchanged | 96-99 | 3.5-7.4 | 0.305 | <1 (low flux) |
References:
- Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
- DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00091
- Venkataramanan R, Ptachcinski R, Burckart G, Yang S, Starzl T, Van Theil D. The Clearance of Cyclosporine by Hemodialysis. The Journal of Clinical Pharmacology 1984; 24, 528-531.