Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

Immunosuppressants Methotrexate Not recommended Administer Post-HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
454 85-100 8-12 N/A 50 0.4-0.8 92.1 63 (high flux)


  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL:
  • Wall S, Johansen M, Molony D, DuBose T, Jaffe N, Madden T. Effective clearance of methotrexate using high-flux hemodialysis membranes. American journal of kidney diseases (the official journal of the National Kidney Foundation) 1996; 28(6), 846-54.