Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

ImmunosuppressantsSirolimusNormal dose based on indicationAdminister Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
914N/A57-63N/A9212N/A0 (N/A)


  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL:
  • Ferron G, Mishina E, Zimmerman J, Jusko W. Population pharmacokinetics of sirolimus in kidney transplant patients. Clinical pharmacology and therapeutics 1997; 61(4), 416-28.