Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

ImmunosuppressantsTacrolimusVaries based on indication and serum concentrationAdminister Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
804<123-462.1-36 (transplant)75-990.55-2.47N/AN/A


  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00864
  • Karamperis N, Povlsen J, Højskov C, Poulsen J, Pedersen A, Jørgensen K. Comparison of the pharmacokinetics of tacrolimus and cyclosporine at equivalent molecular doses. Transplantation Proceedings 2003; 35(4), 1314-1318.
  • Wallemacq P, Verbeeck R. Comparative Clinical - Pharmacokinetics of Tacrolimus in Paediatric and Adult Patients. Clinical Pharmacokinetics 2001; 40(4), 283-295.