Tacrolimus
| Drug Category | Drug | IHD Dosing | Administration Timing Around HD Session |
|---|---|---|---|
| Immunosuppressants | Tacrolimus | Varies based on indication and serum concentration | Administer Anytime During HD |
Molecular Weight (Da) | Excreted Unchanged (%) | Normal Half-Life (Hours) | ESRD Half-Life (Hours) | Plasma Protein Binding (%) | Volume of Distribution (L/kg) | Dialytic Plasma Clearance (ml/min) | % Dialyzed |
|---|---|---|---|---|---|---|---|
| 804 | <1 | 23-46 | 2.1-36 (transplant) | 75-99 | 0.55-2.47 | N/A | N/A |
References:
- DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00864
- Karamperis N, Povlsen J, Højskov C, Poulsen J, Pedersen A, Jørgensen K. Comparison of the pharmacokinetics of tacrolimus and cyclosporine at equivalent molecular doses. Transplantation Proceedings 2003; 35(4), 1314-1318.
- Wallemacq P, Verbeeck R. Comparative Clinical - Pharmacokinetics of Tacrolimus in Paediatric and Adult Patients. Clinical Pharmacokinetics 2001; 40(4), 283-295.