Calcitriol
| Drug Category | Drug | IHD Dosing | Administration Timing Around HD Session |
|---|---|---|---|
| Metabolic Bone Disease Medications | Calcitriol | Dose based on blood work | Administer Anytime During HD |
Molecular Weight (Da) | Excreted Unchanged (%) | Normal Half-Life (Hours) | ESRD Half-Life (Hours) | Plasma Protein Binding (%) | Volume of Distribution (L/kg) | Dialytic Plasma Clearance (ml/min) | % Dialyzed |
|---|---|---|---|---|---|---|---|
| 417 | N/A | 5-8 | 16-22 | 99 | N/A | N/A | <8 (low and high flux) |
References:
- Ash S, Gloeckner P, Barnett S. Lack of Removal Procedures of Calcitriol During Hemodialysis Procedures. Journal of the American Society of Nephrology 1996; 1587-1591.
- DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00136
- Levine B, Song M. Pharmacokinetics and Efficacy of Pulse Oral Versus Intravenous Calcitriol in Hemodialysis Patients. The lancet oncology 1996; 7(3), 488-496.