Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

Metabolic Bone Disease MedicationsCalcitriolDose based on blood workAdminister Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
417N/A5-816-2299N/AN/A<8 (low and high flux)


  • Ash S, Gloeckner P, Barnett S. Lack of Removal Procedures of Calcitriol During Hemodialysis Procedures. Journal of the American Society of Nephrology 1996; 1587-1591.
  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL:
  • Levine B, Song M. Pharmacokinetics and Efficacy of Pulse Oral Versus Intravenous Calcitriol in Hemodialysis Patients. The lancet oncology 1996; 7(3), 488-496.