Sodium thiosulfate
| Drug Category | Drug | IHD Dosing |
Administration Timing Around HD Session |
|---|---|---|---|
| Miscellaneous Medications | Sodium thiosulfate | 12.5-25g IV 3 times per week | Administer Anytime During HD |
|
Molecular Weight (Da) | Excreted Unchanged (%) | Normal Half-Life (Hours) | ESRD Half-Life (Hours) | Plasma Protein Binding (%) | Volume of Distribution (L/kg) | Dialytic Plasma Clearance (ml/min) | % Dialyzed |
|---|---|---|---|---|---|---|---|
| 158 | 28.5 | 0.65 | N/A | N/A | 0.226 | 183 (based on 70 kg) | > 32 (high flux) |
References:
- Farese S, Stauffer E, Kalicki R et al. Sodium thiosulfate pharmacokinetics in hemodialysis patients and healthy volunteers. Clin J Am Soc Nephrol 2011;6,1447-55.
- Guerra G, Shah R, Ross E. Rapid resolution of calciphylaxis with intravenous sodium thiosulfate and continuous venovenous haemofiltration using low calcium replacement fluid: case report. Nephrology, dialysis, transplantation (official publication of the European Dialysis and Transplant Association - European Renal Association) 2005; 20(6), 1260-2.
- Shea M, Koziol J, Howell S. Kinetics of Sodium Thiosulfate, a Cisplatin Neutralizer. Clinical pharmacology and therapeutics 1984; 35(3), 419-425.
- Singh RP, Derendorf H, Ross EA. Simulation-based sodium thiosulfate dosing strategies for the treatment of calciphylaxis. Clin J Am Soc Nephrol 2011;6:1155-9.
Rajendra Pratap Singh,* Hartmut Derendorf,* and Edward A. Ross†