Sodium thiosulfate

Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

Miscellaneous Medications Sodium thiosulfate 12.5-25g IV 3 times per week Administer Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
158 28.5 0.65 N/A N/A 0.226 183 (based on 70 kg) > 32 (high flux)


  • Farese S, Stauffer E, Kalicki R et al. Sodium thiosulfate pharmacokinetics in hemodialysis patients and healthy volunteers. Clin J Am Soc Nephrol 2011;6,1447-55.
  • Guerra G, Shah R, Ross E. Rapid resolution of calciphylaxis with intravenous sodium thiosulfate and continuous venovenous haemofiltration using low calcium replacement fluid: case report. Nephrology, dialysis, transplantation (official publication of the European Dialysis and Transplant Association - European Renal Association) 2005; 20(6), 1260-2.
  • Shea M, Koziol J, Howell S. Kinetics of Sodium Thiosulfate, a Cisplatin Neutralizer. Clinical pharmacology and therapeutics 1984; 35(3), 419-425.
  • Singh RP, Derendorf H, Ross EA.  Simulation-based sodium thiosulfate dosing strategies for the treatment of calciphylaxis. Clin J Am Soc Nephrol 2011;6:1155-9.






    Rajendra Pratap Singh,* Hartmut Derendorf,* and Edward A. Ross