Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

NSAIDs Indomethacin AVOID if possible; 25mg PO Q12H Administer Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
358 30 4-12 Unchanged 99 0.12 19.9 19.6 (low flux)


  • Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL:
  • Skoutakis V, Acchiardo S, Carter C, et al. Dialyzability and pharmacokinetics of indomethacin in adult patients with end-stage renal disease. Drug intelligence & clinical pharmacy. 1986;20(12):956-60.