Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

OpioidsFentanylDose as for normal renal functionAdminister Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
336<102-17 (depend on dosage form)Unchanged80-852-4N/A0 (high and low flux)


  • Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00813
  • Joh J, Sila M, Bastani B. Nondialyzability of Fentanyl with High- Efficiency and High-Flux Membranes. Anesthesia & Analgesia. 1998;86(2):445-51.