Methadone
| Drug Category | Drug | IHD Dosing | Administration Timing Around HD Session |
|---|---|---|---|
| Opioids | Methadone | 50-75% of normal dose | Administer Anytime During HD |
Molecular Weight (Da) | Excreted Unchanged (%) | Normal Half-Life (Hours) | ESRD Half-Life (Hours) | Plasma Protein Binding (%) | Volume of Distribution (L/kg) | Dialytic Plasma Clearance (ml/min) | % Dialyzed |
|---|---|---|---|---|---|---|---|
| 309 | N/A | 13-58 | N/A | 60-90 | 3-6 | 15.5 | 1-18 (low flux) |
References:
- Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
- DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00333
- Furlan, V., Hafi, A., Dessalles M.C., Bouchez, J., Charpentier, B., Taburet AM. Methadone is poorly removed by haemodialysis. Nephrology, dialysis, transplantation (official publication of the European Dialysis and Transplant Association - European Renal Association) 1999;14(1):254-255.
- Kreek MJ, Schecter a J, Gutjahr CL, Hecht M. Methadone use in patients with chronic renal disease. Drug and alcohol dependence. 1980;5(3):197-205.