Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

OpioidsMethadone50-75% of normal doseAdminister Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
309N/A13-58N/A60-903-615.51-18 (low flux)


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