Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

OpioidsOxycodone50% of normal doseAdminister Post-HD; if administer on HD, may need to supplement post

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
315N/A3-4.5N/A452.6N/A32.8-52.6 (low flux) parent drug and metabolites


  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00497
  • Lee M, Leng M, Cooper R, House R. Measurements of plasma oxycodone, noroxycodone and oxymorphone levels in a patient with bilateral nephrectomy who is undergoing haemodialysis. Palliative Medicine. 2005;19(3):259-260.