Oxycodone
Drug Category | Drug | IHD Dosing | Administration Timing Around HD Session |
---|---|---|---|
Opioids | Oxycodone | 50% of normal dose | Administer Post-HD; if administer on HD, may need to supplement post |
Molecular Weight (Da) | Excreted Unchanged (%) | Normal Half-Life (Hours) | ESRD Half-Life (Hours) | Plasma Protein Binding (%) | Volume of Distribution (L/kg) | Dialytic Plasma Clearance (ml/min) | % Dialyzed |
---|---|---|---|---|---|---|---|
315 | N/A | 3-4.5 | N/A | 45 | 2.6 | N/A | 32.8-52.6 (low flux) parent drug and metabolites |
References:
- DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00497
- Lee M, Leng M, Cooper R, House R. Measurements of plasma oxycodone, noroxycodone and oxymorphone levels in a patient with bilateral nephrectomy who is undergoing haemodialysis. Palliative Medicine. 2005;19(3):259-260.