Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

Proton Pump Inhibitors Esomeprazole 20-40mg PO Q24H Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
345.42 N/A 1-1.5 N/A 97 0.23 N/A N/A


    • Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
    • DrugBank [Online]. 2013 Feb 06 [cited 2013 Feb 06]; Available from: URL:
    • Esomeprazole. In: Lexi-Drugs Online. Hudson (OH): Lexi-Comp, Inc,; [updated 02/06/13; accessed 02/06/13].