Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

Proton Pump Inhibitors Omeprazole 20mg PO Q24H Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
345.42 Negligible 0.5-1 Unchanged 95 N/A N/A 0 (Low flux)


    • Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
    • DrugBank [Online]. 2013 Feb 06 [cited 2013 Feb 06]; Available from: URL:
    • Howden CW, Payton CD, Meredith RA , Hughes DMA, Macdougall AI, Reid JL, Forrest JA. Antisecretory effect  and oral pharmacokinetics  of omeprazole in patients with chronic renal failure. Eur J Clin Pharmacol 1985;28:637-40.
    • Omeprazole. In: Lexi-Drugs Online. Hudson (OH): Lexi-Comp, Inc,; [updated 02/06/13; accessed 02/06/13].