Rabeprazole

Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

Proton Pump Inhibitors Rabeprazole 20mg PO Q24H Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
359.44 N/A 1-2 Unchanged 96.3 N/A N/A N/A

References:

    • DrugBank [Online]. 2013 Feb 06 [cited 2013 Feb 06]; Available from: URL:http://www.drugbank.ca
    • Keane WF, Swan SK, GRimes I, Humphries TJ. Rabeprazole: pharmacokinetics and tolerability in patients with stable, end-stage renal failure. J Clin Pharmacol 1999;39:927-33.
    • Rabeprazole. In: Lexi-Drugs Online. Hudson (OH): Lexi-Comp, Inc,; [updated 02/06/13; accessed 02/06/13].