Carbamazepine
| Drug Category | Drug | IHD Dosing | Administration Timing Around HD Session |
|---|---|---|---|
| Psychotropics | Carbamazepine | Normal dose based on indication, titrate according to target level | Administer Post-HD, if feasible; For divided dosing in seizure indication, may require supplemental dose post-HD |
Molecular Weight (Da) | Excreted Unchanged (%) | Normal Half-Life (Hours) | ESRD Half-Life (Hours) | Plasma Protein Binding (%) | Volume of Distribution (L/kg) | Dialytic Plasma Clearance (ml/min) | % Dialyzed |
|---|---|---|---|---|---|---|---|
| 236 | 2-3 | 25-65 (single dosing); 12-17 (chronic dosing) | Unchanged | 75 | 0.8-1.6 | 53.6-77.2 | 9 (low flux), 24-28 (high flux) |
References:
- Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
- DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00564
- Harder J, Heung M, Vilay a M, Mueller B, Segal J. Carbamazepine and the active epoxide metabolite are effectively cleared by hemodialysis followed by continuous venovenous hemodialysis in an acute overdose. Hemodialysis international. International Symposium on Home Hemodialysis. 2011;15(3):412-5.
- Ram Prabahar M, Raja Karthik K, Singh M, et al. Successful treatment of carbamazepine poisoning with hemodialysis: a case report and review of the literature. Hemodialysis international. International Symposium on Home Hemodialysis. 2011;15(3):407-11.