Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

PsychotropicsClobazamNormal Dose based on indicationAdminister Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
301<118N/A83N/AN/ANo (low flux)


  • Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL:
  • Roberts G, Zoanetti G. Clobazam and n-demethylclobazam serum concentrations in endstage renal failure and hemodialysis. Annals of pharmacotherapy. 1994;28(7):966-967.