Lithium
| Drug Category | Drug | IHD Dosing | Administration Timing Around HD Session |
|---|---|---|---|
| Psychotropics | Lithium | 25-50% of normal dose; titrate according to target level | Administer Post-HD |
Molecular Weight (Da) | Excreted Unchanged (%) | Normal Half-Life (Hours) | ESRD Half-Life (Hours) | Plasma Protein Binding (%) | Volume of Distribution (L/kg) | Dialytic Plasma Clearance (ml/min) | % Dialyzed |
|---|---|---|---|---|---|---|---|
| 74 | N/A | 14-28 | 40 | None | 0.5-0.9 | 63-114 | N/A |
References:
- Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
- DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB01356
- Jacosbson D, Assen G, Frederichsen P, Eisenga B. Lithium intoxication: pharmacokinetics during and after terminated hemodialysis in acute intoxications. Journal of toxicology-clinical toxicology. 1987;25(1-2):81-94.
- Eyer F, Pfab R, Felgenhauer N, et al. Lithium poisoning: pharmacokinetics and clearance during different therapeutic measures. Journal of clinical psychopharmacology. 2006;26(3):325-30.