Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

PsychotropicsPhenytoinNormal Dose based on indication; adjust according to target free or corrected total phenytoin levelAdminister Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
2522 7-24Unchanged900.7N/ANo (low flux)


  • Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
  • Dasgupta A, Abu-Alfa A. Increased free phenytoin concentrations in predialysis serum compared to postdialysis serum in patients with uremia treated with hemodialysis: role of uremic compounds. American journal of clinical pathology. 1992;98(1):19-25.
  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: