Valproic acid

Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

PsychotropicsValproic acidNormal Dose based on indication; titrate according to target free valproic acid levelAdminister Post-HD, if feasible; For divided dosing in seizure indication, may require supplemental dose post-HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
144<56-15Unchanged80-90 (increased free fraction due to reduced protein binding in ESRD)0.19-0.23N/A37-57 (high flux)


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