Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

SedativesLorazepam0.5-1mg PO Q8H PRNAdminister Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
321<15-1032-70870.9-1.3828 (low flux)


  • Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00186
  • Morrison G, Chiang S, Koepke H, Walker B. Effect of renal impairment and hemodialysis on lorazepam kinetics. Clinical Pharmacology and Therapeutics. 1984;35(5):646-652.