Oxazepam
| Drug Category | Drug | IHD Dosing | Administration Timing Around HD Session |
|---|---|---|---|
| Sedatives | Oxazepam | 10-30mg PO HS PRN | Administer Anytime During HD |
Molecular Weight (Da) | Excreted Unchanged (%) | Normal Half-Life (Hours) | ESRD Half-Life (Hours) | Plasma Protein Binding (%) | Volume of Distribution (L/kg) | Dialytic Plasma Clearance (ml/min) | % Dialyzed |
|---|---|---|---|---|---|---|---|
| 287 | <1 | 5-10 | 25-90 | 97 | 0.6-1.6 | N/A | 1-2 (low flux) |
References:
- Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
- DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB00842
- Greenblatt D, Murray T, Audet P. Multiple-dose kinetics and dialyzability of oxazepam in renal insufficiency. Nephron. 1983;34(4):234-238.
- Murray T, Chiang S, Koepke H, BR W. Renal disease, age, and oxazepam kinetics. Clinical Pharmacology and Therapeutics. 1981;30(6):805-809.