Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

SedativesZopiclone5-15mg PO HS PRNAdminister Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
389<16-9N/A45N/AN/ANo (low flux)


  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB01198
  • Marc-Aurele J, Caille G, Bourgoin J. Comparison of zopiclone pharmacokinetics in patients with impaired renal function and normal subjects. Effect of hemodialysis. Sleep. 1987;10(S1):22-6.