Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

AntiarrhythmicsAmiodaroneNormal dose based on indicationAdminister Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
645<514-120 daysUnchanged9670-140N/AMinimal (N/A)


  • Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL:
  • Ujhelyi M, Klamerus K, Vadiei K et al. Disposition of intravenous amiodarone in subjects with normal and impaired renal function. The Journal of Clinical Pharmacology 1996;36:122-30.