Amiodarone
| Drug Category | Drug | IHD Dosing | Administration Timing Around HD Session |
|---|---|---|---|
| Antiarrhythmics | Amiodarone | Normal dose based on indication | Administer Anytime During HD |
Molecular Weight (Da) | Excreted Unchanged (%) | Normal Half-Life (Hours) | ESRD Half-Life (Hours) | Plasma Protein Binding (%) | Volume of Distribution (L/kg) | Dialytic Plasma Clearance (ml/min) | % Dialyzed |
|---|---|---|---|---|---|---|---|
| 645 | <5 | 14-120 days | Unchanged | 96 | 70-140 | N/A | Minimal (N/A) |
References:
- Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
- DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB01118
- Ujhelyi M, Klamerus K, Vadiei K et al. Disposition of intravenous amiodarone in subjects with normal and impaired renal function. The Journal of Clinical Pharmacology 1996;36:122-30.