Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

Dyslipidemia Medications (Misc. ) Niacin 250mg PO Q24H, titrate to 500mg PO Q8H Administer Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
123 12 0.5-1 N/A <20 N/A N/A Minimal (high flux)


  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL:
  • Reiche I, Westphal S, Martens-Lobenhoffer J, Tröger U, Luley C, Bode-Böger S. Pharmacokinetics and dose recommendations of Niaspan® in chronic kidney disease and dialysis patients. Nephrology, dialysis, transplantation (official publication of the European Dialysis and Transplant Association - European Renal Association) 2011; 26(1), 276-82.