Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

StatinsAtorvastatin10-80mg PO Q24HAdminister Anytime During HD

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
559<21411-15 (parent); 18-22 (metabolite)985.4 (based on 70 kg)N/AMinimal (N/A)


  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL:
  • Lins R, Matthys K, Verpooten G et al. Pharmacokinetics of atorvastatin and its metabolites after single and multiple dosing in hypercholesterolaemic haemodialysis patients. Nephrology Dialysis Transplantation. 2003;18(5):967-976