Drug CategoryDrugIHD Dosing

Administration Timing Around HD Session

ACE InhibitorsTrandolapril0.5-2mg PO Q24H OR 2mg QHD (thrice weekly)Administer Anytime During HD; Post HD if Hypotensive

Molecular Weight    (Da)

Excreted Unchanged (%)Normal Half-Life (Hours)ESRD Half-Life (Hours)Plasma Protein Binding (%)Volume of Distribution (L/kg)Dialytic Plasma Clearance (ml/min)% Dialyzed
430336-10 (active drug); 24 (trandolaprilat)N/A80, 65-94 ([trandolaprilat] dependent)0.26N/AMinimal (N/A)


  • Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
  • DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL:
  • Zheng S, Nath V, Coyne D. ACE inhibitor-based, directly observed therapy for hypertension in hemodialysis patients. American journal of nephrology. 2007;27(5):522-9.