Cefoxitin
| Drug Category | Drug | IHD Dosing | Administration Timing Around HD Session |
|---|---|---|---|
| Antibiotics | Cefoxitin | 1-2g IV QHD | Administer Post-HD |
Molecular Weight (Da) | Excreted Unchanged (%) | Normal Half-Life (Hours) | ESRD Half-Life (Hours) | Plasma Protein Binding (%) | Volume of Distribution (L/kg) | Dialytic Plasma Clearance (ml/min) | % Dialyzed |
|---|---|---|---|---|---|---|---|
| 427 | 80 | 1 | 13-23 | 41-75 | 0.2 | 1.8 | 13.7 (low flux) |
References:
- Aronoff GR, Bennett WM, Berns JS, Brier ME, Kasbekar N, Mueller BA, et al. Drug Prescribing in Renal Failure. Philadelphia: American College of Physicians;2007.
- DrugBank [Online]. 2012 Apr 12 [cited 2012 May 6]; Available from: URL: http://www.drugbank.ca/drugs/DB01331
- Humbert A, Fillastre J, Leroy A, Godin M, Winzum C, Humbert G. Pharmacokinetics of Cefoxitin in Normal Subjects and in Patients with Renal Insufficiency. Reviews Of Infectious Diseases 1979; 1(1), 118-26.
- Schrogie J, Davies R, Yeb K et al. Bioavailability and pharmacokinetics of cefoxitin sodium. Journal of Antimicrobial Chemotherapy 1978; 4(Suppl B), 69-78.